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From human growth and development to disease pathways and progression to gene expression, stem cells offer powerful research potential. In the fast-paced world of healthcare and genetics research, scientists need access to the biomaterials, equipment, and processing that enable their research. But when researchers have limited resources, the entire scientific community misses out on valuable contributions.
In an effort to expand knowledge and treatment options through global collaboration, the US National Institutes of Health (NIH) introduced pluripotent stem cell (iPSC) collections to not-for-profit, academic, and commercial researchers around the world. Two of the largest collections come from the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH). Catalogs of the biosamples in these collections are available online:
These cell line collections are stored, processed, and maintained at Infinity BiologiX’s stem cell repository and are available for distribution worldwide.
iPSC Resources for Global Research
Biosamples in these collections are a powerful and flexible tool for research on genetics and molecular pathways of disease. Stem cells offer the opportunity to model development of disease progression within developing cells. This is because as the cells grow their differentiation process is very similar to what occurs in the human body, so it’s possible to observe how a disease progresses in a growing cell.
They also offer an alternative to mouse or other animal models. By making human brain cells or others, researchers can study mental health and other diseases which are generally more challenging to model in animals.
To further promote access to iPSC biomaterials in the scientific community and biobanking’s role, Dr. Jennifer Moore, Infinity BiologiX’s Senior Director of Advanced Sample Processing Services, will present a poster at the International Society for biological and environmental repositories (ISBER) 2021 Annual Meeting May 10-14.
Her poster, “Infinity BiologiX – a global stem cell resource” highlights the range of stem cell services available including source cell and induced pluripotent stem cells (iPSC) banking, iPSC generation, iPSC gene editing and source cell and iPSC distribution.
In addition to prepared cell line collections offered by NINDS and NIMH, Infinity BiologiX can prepare cells for researchers on demand using existing materials in its biorepository. Isogenetic pairs can also be made using CRISPR/Cas9 genetic editing. The process involves taking disease specific induced pluripotent stem cells from a subject with a known genetic condition, locating, and correcting the mutation in the DNA. The result is two cell lines with matching genetics, one with the mutation and one without it.
Each stem cell collection has its own quality control requirements; however, at minimum, every cell line has undergone testing to verify that it is sterile and will be viable upon thawing. Cells’ identities are also confirmed from the subject. Infinity BiologiX also verifies iPSCs for markers of stemness, including that they are capable of differentiation and are not already partially differentiated.
Source cells used for the iPSCs are either fibroblasts or erythroblasts (a cell type found in peripheral blood) and can be obtained from a skin punch biopsy or a blood draw. All reprogramming is “footprint free,” meaning there is no change to the subject’s genome, and no integrating viruses in the material.
Dr. Moore’s poster will be available to view in ISBER’s virtual poster hall during the entire meeting, and two live sessions will also be held:
- Session 1: Tuesday May 11, 4-5 p.m.
- Session 2: Thursday May 13, 4-5 p.m.
Full-service Biobanking and Support
In addition to stem cell material, Infinity BiologiX offers a wide range of services including storage, processing, and preparation of samples for clinical trials, as well as support for lab work, DNA extraction, and more. Materials can be shipped globally.
These biomaterials can be used to obtain knowledge and research data for product development; however, materials may not be used to create or manufacture the product itself. There are no licensing fees or reach-through intellectual property restrictions on cell line collections. Customers are solely responsible for due diligence regarding any existing intellectual property matters related to their own research. By providing access to equipment and processes, Infinity BiologiX helps researchers scale studies up or incorporate laboratory processes that they do not routinely perform. Also, organizations lacking facilities to house their own collections can elect to outsource storage and even make their materials available to the larger scientific community if they choose.
Comprehensive biobanking and outsourcing lab services are critical to making research accessible and efficient. At Infinity BiologiX we’re always expanding our capabilities, so please contact us to discuss your project!Tags: stem cell research